Does IV Drip Therapy Make You Sleepy? Exploring the Effects

Many people seek the benefits of IV drip therapy, and while most experience these benefits without any post-treatment complaints, some recipients report feeling sleepy afterward. This raises concerns: Is there an underlying cause, or is this a normal reaction? Does IV drip therapy make you sleepy?

No, IV drip therapy usually doesn’t make you sleepy. Feeling sleepy after IV drip therapy can be due to several factors. It may be due to the body’s reaction to high concentrations of nutrients and fluids, the calming effects of components like magnesium in the IV solution, or the relaxing setting during treatment. The addition of antihistamines or pain relievers in the IV can also cause drowsiness.

Keep reading to explore the science behind IV drip therapy, factors that might cause sleepiness after IV, and how it varies from person to person.

Why Do I Feel Sleepy After IV Drip?

You may feel sleepy after IV drip due to several factors. Ingredients such as magnesium in the drip and certain medications can induce relaxation and drowsiness. The process of rehydrating and replenishing nutrients can also lead your body to a restful state. Additionally, the relaxing setting of the therapy session might contribute to feelings of sleepiness. 

Here is a breakdown of the factors in depth:

1. Relaxation Response

Often, the setting in which IV therapy is administered—a calm clinic or a quiet room—combined with the physical sensation of receiving fluids can lead to a state of relaxation. This calming environment can make patients feel sleepy during and shortly after the procedure.

2. Specific Components in the IV

Certain elements commonly found in IV drips, such as magnesium, are known for their relaxing properties. Magnesium, for example, helps regulate neurotransmitters that calm the nervous system. If included in high doses in an IV drip, it could contribute to feelings of tiredness.

3. Underlying Health Conditions

For patients receiving IV therapy for medical reasons, underlying health issues or the body’s response to healing might also lead to fatigue. For example, individuals receiving IV therapy as part of treatment for chronic fatigue syndrome or recovery from an illness might already be prone to sleepiness.

4. Side Effects of Medications

The actual content of the IV drip plays a crucial role in determining its effects on your energy levels. Vitamin-infused drips aimed at boosting energy typically contain a cocktail of B vitamins and vitamin C, which are intended to enhance vitality rather than induce sleep.

Conversely, drips that include certain anti-nausea medications, sedatives, or other medications for pain and anxiety may indeed make a patient feel sleepy. 

5. Body Natural Response

Some people report short-lived mild fatigue after IV therapy. This is thought to be the body’s natural response to increased cellular metabolism, a process that uses energy. It is commonly seen after receiving high concentrations of nutrients and fluids.

6. Long Treatment Duration

Long infusion sessions lasting for hours can lead to fatigue and sleepiness due to the prolonged period of relaxation. This is normal and nothing to worry about.

Personal Experiences Vary

It’s important to note that individual responses to IV drip therapy can vary widely. Factors such as personal health, the specific formulations of the drip, and individual tolerances to the substances administered all play significant roles in how one might feel post-treatment.


IV drip therapy doesn’t inherently cause sleepiness—much depends on the specific ingredients and the individual’s circumstances and health condition. If you’re considering IV therapy and are concerned about potential drowsiness, consult with your healthcare provider about the ingredients in your specific drip. They can help tailor the treatment to your needs, ensuring you receive the benefits you’re seeking without unwanted side effects.